Positive for CK7 means that the CK7 protein was seen inside the cells of interest in the tissue sample. Reactive is another term that pathologists use to describe cells that are producing CK7.
What does cytokeratin positive mean?
Cytokeratin 5/6 is a positive marker for malignant pleural mesothelioma, found in more than three-fourths of cases. It is also found in certain types of lung cancers and breast cancers.
What is CK7 positive in lung cancer?
CK7 can be specifically expressed in certain cancers, which has been verified to be expressed in lung cancer of the present study; besides, the expression of CK7 is a sign of dedifferentiation, positive cells of CK7 may therefore be relatively lower differentiation cells with high degree of malignancy.
Is cytokeratin a tumor marker?
Cytokeratin tumor markers can accurately predict disease status before conventional methods and offer a simple, noninvasive, cheap, and reliable tool for more efficient management.
What is ck in breast cancer?
Cytokeratin (CK) immunohistochemistry can play an important role in breast carcinoma evaluation. We evaluated the expression of a panel of commonly used CKs in a large cohort of breast cancers and assessed its correlation with other biomarkers and breast cancer subtypes.
What is cytokeratin 20 a marker of?
Cytokeratin 20 is a sensitive and specific marker for Merkel cell carcinoma and is helpful in distinguishing between Merkel cell carcinoma and other malignant and benign neoplasms.
Is cytokeratin an antibody?
Description: The monoclonal antibodies AE1 and AE3 recognize many of the acidic and basic cytokeratin family members. Cytokeratins are intermediate filament proteins comprising one component of the cytoskeleton.
Cytokeratin 7 (CK7) is a type II basic low molecular weight cytokeratin that is found in simple epithelia in a variety of organs, including all epithelia in the female genital tract. 305,306. Epithelial tumors of the ovary and fallopian tube all exhibit cytoplasmic and/or membrane staining for CK7.
What is CK7 and CK20 positive?
According to several studies the multi-marker phenotype CK20+/CK7− is observed in colorectal cancer in approximately 75–95%2, 14 of cases whereas the multi-marker phenotype CK20−/CK7+ favors primary tumors of the lung, breast, biliary tract, pancreas, ovary and endometrium.
Is CK7 positive in squamous cell carcinoma?
CK7 was positive in 31.6% of all cases, with varying positivity according to the site. CK20 was negative in all cases except 1 lung.