The mere comparison of strength between the two characters is crazy. Goku is an extraterrestrial being who has to lose a fight in order to get stronger. Saitama is a man that can defeat any foe with a single punch. If the two of them were to face off in a one-on-one battle, Saitama would easily win.
Can Saitama destroy Goku?
Just one punch is all it'll take for Saitama to beat Goku. ... However, Saitama's strength is often undermined by fans when compared to Goku. For instance, yes, Goku is a Saiyan, an alien warrior race, who has the ability to enhance his strength by transforming into a Super Saiyan.