Holidays and Traditions What are the early warning signs of sepsis? What are the early warning signs of sepsis? - confusion or disorientation, - shortness of breath, - high heart rate, - fever, or shivering, or feeling very cold, - extreme pain or discomfort, and. - clammy or sweaty skin. Related Posts:What are the chances of surviving sepsis?Can sepsis occur suddenly?How do you donate to sepsis?How did the yellow fever start?