CC chemokine receptor 2 (CCR2) is the chemokine receptor, which regulates the mobilization of monocytes from bone marrow to the inflammatory sites, and it has been extensively studied in CNS inflammation.2 Jul 2014
Where is CCR2?
This CCR2 gene is located in the chemokine receptor gene cluster region.
What cell types express CCR2?
CCR2 has been found to be expressed by multiple cell types including monocytes, dendritic cells (DCs), endothelial cells, and cancer cells [51,52,53,54].29 May 2020
Where is CCR7 found?
lymphoid tissues
What is the CCR2 gene?
CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include Human Immunodeficiency Virus Type 1 and Idiopathic Anterior Uveitis. Among its related pathways are Peptide ligand-binding receptors and Defensins. An important paralog of this gene is CCR5.
What cells have CCR2?
CCR2 has been found to be expressed by multiple cell types including monocytes, dendritic cells (DCs), endothelial cells, and cancer cells [51,52,53,54]. CCL2 functions through binding to CCR2, one of 19 members of the human chemokine receptor family [55].29 May 2020
What binds to CCR2?
MCP-1, which binds only to CCR2, is a weak chemoattractant of basophils but a potent stimulus of exocytosis (24). MCP-1 and MCP-3 strongly induce histamine release from human basophils, and they, along with MCP-4, readily compete for binding to CCR2 (12).
What cells express chemokine receptors?
Chemokine receptors are seven-transmembrane proteins expressed on neutrophils, lymphocytes, dendritic cells, and many other cell types.
Do B cells express CCR2?
CCR2 was highly expressed by inflammatory monocytes, dendritic cells, plasmacytoid dendritic cells and NK cells in all tissues. CCR2 expression in T cells, B cells and NK T cells was greatest in the BM compared to other tissues.CCR2 was highly expressed by inflammatory monocytes, dendritic cells, plasmacytoid dendritic cellsplasmacytoid dendritic cellsPlasmacytoid dendritic cells (pDCs) are a rare type of immune cell that are known to secrete large quantities of type 1 interferon (IFNs) in response to a viral infection. They develop from bone marrow hematopoietic stem cells and constitute < 0.4% of peripheral blood mononuclear cells (PBMC).https://en.wikipedia.org › wiki › Plasmacytoid_dendritic_cellPlasmacytoid dendritic cell - Wikipedia and NK cells in all tissues. CCR2 expression in T cells, B cells and NK T cells was greatest in the BM compared to other tissues.24 Jul 2015
Do macrophages express CCR2?
CCR2 can be expressed by both hematopoietic cells such as macrophages and nonhematopoietic cells such as endothelial cells,51 fibroblasts,52 and mesenchymal stem cells.
What is CCR2 a marker for?
CCR2 is the main chemokine receptor inducing macrophage and monocyte recruitment to sites of inflammation, and it is also expressed on T cells. To assess whether CCR2 directly regulates T cell responses, we followed the fates of CCR2−/− T cells in T cell–specific inflammatory models.15 Jun 2017
What cells express CCR2?
CCR2 was highly expressed by inflammatory monocytes, dendritic cells, plasmacytoid dendritic cells and NK cells in all tissues. Unexpectedly, more than 60% of neutrophils expressed CCR2, albeit at low levels. CCR2 expression in T cells, B cells and NK T cells was greatest in the BM compared to other tissues.CCR2 was highly expressed by inflammatory monocytes, dendritic cells, plasmacytoid dendritic cellsplasmacytoid dendritic cellsPlasmacytoid dendritic cells (pDCs) are a rare type of immune cell that are known to secrete large quantities of type 1 interferon (IFNs) in response to a viral infection. They develop from bone marrow hematopoietic stem cells and constitute < 0.4% of peripheral blood mononuclear cells (PBMC).https://en.wikipedia.org › wiki › Plasmacytoid_dendritic_cellPlasmacytoid dendritic cell - Wikipedia and NK cells in all tissues. Unexpectedly, more than 60% of neutrophils expressed CCR2, albeit at low levels. CCR2 expression in T cells, B cells and NK T cells was greatest in the BM compared to other tissues.24 Jul 2015