Once in the blood, THC is bound to blood proteins and carried throughout the body where it is either absorbed into body tissues (including the brain, heart, and fat) or transformed by the liver into11-hydroxy-THC and carboxy-THC.
What enzyme metabolizes THC?
Metabolism of THC occurs primarily within the liver by hydroxylation and oxidation reactions catalyzed the cytochrome P450 (CYP450) enzymes; with members of the CYP450-2C subfamily of isoenzymes playing the major role in rodents and humans4,5.May 20, 2019
How is THC metabolized in the body?
THC is rapidly broken down and modified into molecules known as metabolites. At least 80 different metabolites are formed from THC and may have their own effects on the body's endocannabinoid system. These metabolites are stored in body fat and are gradually eliminated from the body through feces and urine.Aug 13, 2020
What enzyme metabolises THC?
Researchers investigated liver enzymes and confirmed previous studies showing that that CYP2C9 is the major enzyme responsible for the elimination of THC and for the creation of 11-OH-THC.
Is THC metabolized by CYP3A4?
Both THC and CBD are metabolized by CYP3A4. THC is also metabolized by CYP2C9, and CBD by CYP2C19. When cannabis or CBD is taken along with certain prescription drugs, THC and CBD can inhibit or induce the metabolic process.Oct 8, 2019
How does THC degrade over time?
Over time, it begins to lose its aroma and potency. According to some older research, weed loses roughly 16 percent of its THC after 1 year, and it just keeps dropping from there: 26 percent THC lost after 2 years.
What causes metabolic rate to increase?
Amount of physical activity – hard-working muscles need plenty of energy to burn. Regular exercise increases muscle mass and teaches the body to burn kilojoules at a faster rate, even when at rest. Drugs – like caffeine or nicotine, can increase the BMR.
What is the best way to increase a person's metabolic rate?
- Protein-rich foods. Protein-rich foods — such as meat, fish, eggs, dairy, legumes, nuts, and seeds — could help increase your metabolism for a few hours. ...
- Mineral-rich foods. ...
- Chili peppers. ...
- Coffee. ...
- Tea. ...
- Beans and legumes. ...
- Ginger. ...
- Cacao.