The best replacement for R-22 Freon is usually R-407cR-407cR-407C is a mixture of hydrofluorocarbons used as a refrigerant. It is a zeotropic blend of difluoromethane (R-32), pentafluoroethane (R-125), and 1,1,1,2-tetrafluoroethane (R-134a). ... R-407C cylinders are colored burnt orange. This refrigerant is intended as a replacement for R-22.https://en.wikipedia.org › wikiR-407C - Wikipedia. It has a very low loss in capacity (0 – 5%) relative to R-22 and is less expensive than many other R-22 replacement refrigerants. If a system has R22 in it already you cannot use a replacement refrigerant to simply add to the R22.Aug 19, 2020