BMP4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog (released from the ventral portion of the notochord) to establish a dorsal-ventral axis for the differentiation of later structures. BMP4 stimulates differentiation of overlying ectodermal tissue.
Do humans have BMP4?
In humans, BMP4 expression is localized to the optic vesicle and optic cup, consistent across species prior to lens formation. In the brain, BMP4 is expressed in the ventral diencephalon which is consistent with its known role in pituitary development, and is also expressed in the medial ganglionic eminence.
Is BMP4 a cytokine?
BMP4: A Stem Cell Therapy Growth Factor (Cytokine)
Is BMP4 secreted?
Bone morphogenetic protein 4 (BMP4) is a potent growth factor that is involved in many important biological processes. Regulation of the level of secreted mature BMP4 determines the biological effects of BMP4 on cells in the local microenvironment.
What is the role of BMP4?
Function. BMP4 is a polypeptide belonging to the TGF-β superfamily of proteins. It, like other bone morphogenetic proteins, is involved in bone and cartilage development, specifically tooth and limb development and fracture repair. Bone morphogenetic proteins are known to stimulate bone formation in adult animals.
What is BMP4 gene?
BMP4 (Bone Morphogenetic Protein 4) is a Protein Coding gene. Diseases associated with BMP4 include Microphthalmia, Syndromic 6 and Orofacial Cleft 11. Among its related pathways are Phospholipase-C Pathway and ERK Signaling.