Buprenorphine, a mu-opioid partial agonist and kappa antagonist, has received attention recently for its possible role as a mood regulator.
Does Suboxone help you relax?
Suboxone can make you feel very relaxed, which puts you at risk for developing a dependence on it while you work to break your reliance on opioids.
What are the benefits of buprenorphine?
- Diminish the effects of physical dependency to opioids, such as withdrawal symptoms and cravings.
- Increase safety in cases of overdose.
- Lower the potential for misuse.
Is buprenorphine good for depression?
Studies have shown that patients treated with buprenorphine exhibit significant improvement in depressive symptoms, as measured with the Hamilton Rating Scale for Depression (HAM-D), specifically with reduction in depressed mood, fatigue, and hopelessness (1).6 Feb 2019
Does buprenorphine cause shortness of breath?
This drug may cause very bad and sometimes deadly breathing problems. Call your doctor right away if you have slow, shallow, or trouble breathing.6 days ago
Does Suboxone suppress your breathing?
Because Suboxone is a partial opioid agonist, it can cause respiratory depression as opioids can. Respiratory depression is a condition in which breathing becomes too shallow or slow, causing a lack of oxygen in the body. Respiratory depression is perhaps the most severe of the side effects of Suboxone.
Why does buprenorphine cause respiratory depression?
Norbuprenorphine, a metabolite of buprenorphine via CYP3A4 causes dose-dependent respiratory depression, perhaps mediated by opioid receptors in the lung rather than the brain, and is ten times more potent than buprenorphine [15].
What medicines interact with buprenorphine?
Some products that may interact with this drug include: certain pain medications (mixed opioid agonist-antagonists such as butorphanol, nalbuphine, pentazocine), naltrexone, samidorphan.
Who should not take buprenorphine?
You should not use buprenorphine if you are allergic to it, or: if you have used another narcotic drug within the past 4 hours.
Which medicines should not be taken together?
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Antacids.
- Decongestants, such as dextromethorphan or pseudoephedrine.
- First-generation antihistamines.
- Certain foods.
- Herbal products and minerals.
- Histamine2 (H2)-receptor antagonists such as cimetidine and ranitidine.
What is the difference between buprenorphine and buprenorphine hydrochloride?
Buprenorphine hydrochloride is a partial agonist at mu opioid receptors, and a very weak partial agonist at kappa opioid receptors and an even weaker partial agonist at delta opioid receptors. On the other hand, buprenorphine has a similar high affinity for all three opioid receptor subtypes.
What is buprenorphine hydrochloride used for?
Generic Name: buprenorphine HCl Buprenorphine is used to treat dependence/addiction to opioids. Buprenorphine belongs to a class of drugs called mixed opioid agonist-antagonists. It helps prevent withdrawal symptoms caused by stopping other opioids.